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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Benign oligemia despite a malignant MRI profile in acute ischemic stroke

Oh Young Bang1, Kwang Ho Lee, Suk Jae Kim

  • 1Department of Neurology and the Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|April 14, 2010
PubMed
Abstract

Insights

Diffusion and perfusion MRI may not always predict outcomes in acute ischemic stroke. These imaging techniques, while indicating severe perfusion delays, did not correlate with patient outcomes in two middle cerebral artery occlusion cases.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Diffusion and perfusion MRI are being explored to identify patient subgroups for reperfusion therapies in acute ischemic stroke.
  • These advanced MRI techniques aim to predict treatment response and potential harm.

Purpose of the Study:

  • To investigate the utility of serial MRI findings in patients with proximal middle cerebral artery occlusion.
  • To evaluate the correlation between advanced MRI profiles and clinical outcomes in acute ischemic stroke.

Main Methods:

  • Analysis of serial MRI data, including diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI).
  • Case report of two patients with proximal middle cerebral artery occlusion and malignant MRI profiles.

Main Results:

  • Both patients presented with acute cortical infarcts and extensive perfusion delays on DWI and PWI, suggesting a malignant MRI profile.
  • Despite severe perfusion delays and persistent arterial occlusion, neither patient developed new ischemic lesions or hemorrhage.
  • Both patients recovered without neurological sequelae.

Conclusions:

  • Time-domain perfusion-weighted imaging (PWI) findings in acute ischemic stroke require cautious interpretation.
  • The presence of a malignant MRI profile does not invariably predict poor outcomes or complications in all acute ischemic stroke cases.
Keywords:
collateralsischemiamagnetic resonance imagingperfusionstroke

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