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Updated: Jun 13, 2026

05:17
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
The first F-ring modified ciguatoxin analogue showing significant toxicity
Yuuki Ishihara1, Nayoung Lee, Naomasa Oshiro
1Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Abstract:
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are potent neurotoxic polycyclic ethers. We report herein the total synthesis of a 10-membered F-ring analogue of 51-hydroxyCTX3C, which constitutes the first example of an F-ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity.

