Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients
Seyed Adel Moallem1, Fatemeh Nazemian, Sepideh Eliasi
1Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Cathepsin D may play a role in atherosclerosis development. This study found a significant positive correlation between serum cathepsin D levels and carotid intima-media thickness in hemodialysis patients, suggesting its potential as an atherosclerosis marker.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Cardiovascular disease is the primary cause of mortality in hemodialysis patients.
- Atherosclerosis is a frequent complication in end-stage renal disease (ESRD).
- Cathepsin D is a potential biomarker for atherosclerosis.
Purpose of the Study:
- To investigate the association between serum cathepsin D concentrations and carotid intima-media thickness (CIMT) in hemodialysis patients.
- To explore the role of cathepsin D in the development of atherosclerosis in this population.
Main Methods:
- Serum levels of soluble cathepsin D were measured using an enzyme-linked immunosorbant assay (ELISA).
- Carotid intima-media thickness (CIMT) was assessed in 31 hemodialysis patients.
- Pearson correlation was employed to analyze the relationship between cathepsin D and CIMT.
Main Results:
- A significant positive correlation was observed between serum cathepsin D levels and CIMT (P < 0.05).
- Higher cathepsin D concentrations were associated with increased CIMT in hemodialysis patients.
Conclusions:
- Cathepsin D may contribute to the development of atherosclerotic plaques in hemodialysis patients.
- Serum cathepsin D could serve as a potential marker for atherosclerosis in ESRD patients undergoing hemodialysis.
Aim:
Cardiovascular (CV) disease is the leading cause of death in hemodialysis (HD) patients, and approximately half of mortalities in HD patients are attributed to CV disease. Atherosclerosis is the most frequent cause of CV complications in patients with end-stage renal disease (ESRD). Based on recent studies, cathepsin D has been suggested as a potential marker of atherosclerosis, and we hypothesized that there is an association between serum concentration of cathepsin D and carotid intima-media thickness (CIMT) in hemodialysis patients.
Methods:
Thirty-one hemodialysis patients (18 men and 13 women) were enrolled in this study. Serum levels of soluble cathepsin D were measured with an enzyme-linked immunosorbant assay (ELISA) kit. CIMT was determined in each patient.
Results:
The data showed that there was a positive significant correlation between serum concentration of cathepsin D and CIMT by using Pearson correlation (P value <0.05).
Conclusion:
Based on the results of this study, cathepsin D could be suggested to have a role in the development of atherosclerotic plaques.
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