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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: Jun 13, 2026

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

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Published on: April 16, 2019

Progress in siRNA delivery using multifunctional nanoparticles.

Weiwei Gao1, Zeyu Xiao, Alex Radovic-Moreno

  • 1Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 14, 2010
PubMed
Summary

Synthetic polymer nanoparticles are engineered for effective small interfering RNA (siRNA) delivery. This review highlights multifunctional designs for improved encapsulation, targeting, and intracellular release of siRNA therapeutics.

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Last Updated: Jun 13, 2026

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

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Published on: April 16, 2019

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Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Area of Science:

  • Biotechnology
  • Materials Science
  • Pharmacology

Background:

  • Synthetic polymer nanoparticles are crucial for nucleic acid delivery.
  • Effective delivery requires efficient siRNA encapsulation, active targeting, and intracellular release.

Purpose of the Study:

  • To review recent advancements in designing polymeric nanoparticles for siRNA delivery.
  • To explore multifunctional approaches for enhanced siRNA therapeutics.

Main Methods:

  • Review of current literature on polymeric nanoparticle design for siRNA.
  • Analysis of strategies for nanoparticle encapsulation, targeting, and release.

Main Results:

  • Multifunctional nanoparticle designs show promise for improved siRNA delivery.
  • Engineering strategies focus on optimizing encapsulation efficiency, site-specific targeting, and endosomal escape.

Conclusions:

  • Advanced polymeric nanoparticles offer a viable platform for siRNA delivery.
  • Multifunctional design is key to overcoming challenges in intracellular siRNA therapeutics.