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Updated: Jun 13, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
The first provocative test for coronary artery spasm at the Cleveland Clinic
1Baptist Hospital, Miami, FL, USA. wonderwayne@earthlink.net
Abstract:
This article provides narration of the events during the development of ergonovine maleate infusions for detecting coronary artery spasm at the Cleveland Clinic in 1973. This was the first safe, reproduceable and reliable test for angiographic visualization of the pathophysiology associated with the Prinzmetal Syndrome termed "angina inversa".
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