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Updated: Jun 13, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
[Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism]
Hong-xia Liang1, Zu-jiang Yu, He-qing Jiang
1The Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
The HLA-DRB1 * 1301/1302 gene variant is linked to increased susceptibility to severe chronic hepatitis B. Other tested HLA-DRB1 gene variants showed no significant association with this condition.
Area of Science:
- Immunogenetics
- Hepatology
- Molecular Biology
Context:
- Chronic hepatitis B is a significant global health concern.
- Understanding genetic predispositions is crucial for managing severe disease.
- Human Leukocyte Antigen (HLA) genes play a role in immune responses to viral infections.
Purpose:
- To investigate the association between Human Leukocyte Antigen - DRB1 (HLA-DRB1) gene polymorphism and the risk of developing severe chronic hepatitis B.
- To identify specific HLA-DRB1 alleles that may confer susceptibility or resistance to severe chronic hepatitis B.
Summary:
- This study analyzed HLA-DRB1 gene polymorphism in 26 patients with severe chronic hepatitis B and 45 healthy controls using polymerase chain reaction-sequence specific primers.
- Results indicated a significantly higher frequency of the HLA-DRB1 * 1301/1302 allele in the severe chronic hepatitis B group compared to controls.
- No significant difference in frequencies was observed for HLA-DRB1 * 1201/1202 and * 1501/1502 alleles between the groups.
Impact:
- The findings suggest that HLA-DRB1 * 1301 and * 1302 alleles are closely associated with susceptibility to severe chronic hepatitis B.
- This genetic association may inform future risk stratification and personalized treatment strategies for hepatitis B.
- Further research can explore the immunological mechanisms underlying this association.
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