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Updated: Jun 13, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

[The correlation factor about respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infant]

Man Tian1, De-yu Zhao, Guan-yu Wen

  • 1Department of Respiratory Medicine, the Affiliated Nanjing Children's Hospital of NJMU, Nanjing 210008, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|April 15, 2010
PubMed

Insights

Early-life respiratory syncytial virus (RSV) bronchiolitis is linked to recurrent wheezing. Key risk factors include not breastfeeding, smoke exposure, and vitamin deficiencies, increasing the risk for RSV bronchiolitis and subsequent wheezing in children.

Area of Science:

  • Pediatric respiratory health
  • Viral infections and immunology
  • Environmental health impacts

Context:

  • Respiratory syncytial virus (RSV) bronchiolitis is a common early-life respiratory illness.
  • Recurrent wheezing post-bronchiolitis poses a significant health concern for children.
  • Identifying risk factors is crucial for prevention and management strategies.

Purpose:

  • To investigate the correlation between early-life RSV bronchiolitis and recurrent wheezing over two years.
  • To identify significant risk factors for RSV bronchiolitis and subsequent wheezing.
  • To analyze the influence of atopy, environmental exposures, and nutritional status.

Summary:

  • Not breastfeeding, exposure to cigarette smoke, and deficiencies in Vitamins A and D were identified as significant risk factors for RSV bronchiolitis.
  • Subsequent wheezing was associated with cigarette smoke exposure, vitamin deficiencies, and personal or familial history of atopy.
  • Biomarkers such as eosinophilia, high serum IgE, RANTES, and a decreased TH1 to TH2 ratio were linked to post-bronchiolitis wheezing.

Impact:

  • Findings highlight modifiable risk factors like breastfeeding and smoke avoidance for preventing RSV bronchiolitis.
  • The study provides insights into the immunological underpinnings of post-bronchiolitis wheezing.
  • Results can inform public health initiatives and clinical guidelines for managing pediatric respiratory illnesses.
Abstract

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