Related Experiment Video

Updated: Jun 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Lower extremity deep vein thrombosis associated with gluten-sensitivity celiac disease]

E N Baryshnikov, L M Krums, N N Vorob'eva

    Terapevticheskii Arkhiv
    |April 15, 2010
    PubMed

    Insights

    Gluten-sensitivity celiac disease (GSCD) is linked to a higher risk of blood clots. Deficiencies in homocysteine, protein S, folate, and vitamin B12 may contribute to this thrombophilia in GSCD patients.

    Area of Science:

    • Internal Medicine
    • Gastroenterology
    • Hematology

    Background:

    • Gluten-sensitivity celiac disease (GSCD) is an autoimmune disorder triggered by gluten ingestion.
    • Thrombosis, or blood clot formation, is a serious medical condition with various underlying causes.
    • The association between GSCD and an increased risk of thrombosis is increasingly recognized in medical literature.

    Observation:

    • This paper presents a clinical case of a female patient diagnosed with GSCD.
    • The patient experienced recurrent lower extremity vein thrombosis.
    • This case highlights a potential link between GSCD and thrombotic events.

    Findings:

    • Literature suggests that GSCD is associated with an elevated risk of thrombosis.
    • Potential contributing factors to thrombophilia in GSCD include hyperhomocysteinemia and deficiencies in protein S, folate, and vitamin B12.
    • Antiphospholipid syndrome is another condition that may be associated with GSCD.

    Implications:

    • Understanding the link between GSCD and thrombosis is crucial for risk assessment and patient management.
    • Screening for thrombophilia in GSCD patients may be warranted.
    • Further research is needed to elucidate the exact mechanisms connecting GSCD, nutrient deficiencies, and thrombosis.

    More Related Videos

    Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component07:39

    Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component

    Published on: September 1, 2023

    Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis06:45

    Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

    Published on: February 10, 2023

    Related Concept Videos

    Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

    Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

    The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
    Venous Thrombosis I: Introduction01:30

    Venous Thrombosis I: Introduction

    Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
    Veins of Lower Limbs01:15

    Veins of Lower Limbs

    The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
    Formed by the union of the medial and lateral plantar veins, the posterior tibial vein, rising through the calf muscle, assimilates the fibular vein. The anterior tibial vein, a superior extension of the foot's dorsalis pedis vein, merges with the posterior tibial vein at the knee,...
    Other Disorders of Digestive System01:30

    Other Disorders of Digestive System

    The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
    Venous Thrombosis III: Interprofessional Care01:29

    Venous Thrombosis III: Interprofessional Care

    Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
    Assessment of the Cardiovascular System III: Palpation01:27

    Assessment of the Cardiovascular System III: Palpation

    Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
    Jugular Venous Pressure (JVP) Measurement
    Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...