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Related Experiment Video

Updated: Jun 13, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Endothelial dysfunction in patients with systemic lupus erythematosus].

S Iu Serikova, N L Kozlovskaia, E M Shilov

    Terapevticheskii Arkhiv
    |April 15, 2010
    PubMed
    Summary

    Endothelial dysfunction (ED) is common in systemic lupus erythematosus (SLE), affecting 40% of patients. A new method using volumetric compression oscillometry offers a viable clinical approach to assess ED in SLE patients.

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    Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
    06:35

    Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

    Published on: April 27, 2016

    Related Experiment Videos

    Last Updated: Jun 13, 2026

    Assessment of Vascular Function in Patients With Chronic Kidney Disease
    08:50

    Assessment of Vascular Function in Patients With Chronic Kidney Disease

    Published on: June 16, 2014

    Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
    06:35

    Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

    Published on: April 27, 2016

    Area of Science:

    • Cardiovascular Science
    • Rheumatology
    • Vascular Biology

    Context:

    • Systemic lupus erythematosus (SLE) is associated with a high prevalence of endothelial dysfunction (ED).
    • Clinical data on ED in SLE patients are limited due to diagnostic challenges.
    • Existing diagnostic methods for ED require modification for SLE assessment.

    Purpose:

    • To investigate the prevalence and clinical correlates of ED in SLE patients.
    • To evaluate a novel method for assessing endothelial function using volumetric compression oscillometry.
    • To compare the proposed method with standard ultrasound techniques for ED evaluation.

    Summary:

    • ED was detected in 40% of SLE patients studied.
    • ED development correlated with SLE activity, Raynaud's syndrome, elevated systolic blood pressure, plasma fibrinogen, and high-dose prednisone.
    • Volumetric compression oscillometry demonstrated diagnostic capacity comparable to standard ultrasound methods for evaluating endothelial status.

    Impact:

    • Highlights the significant prevalence of ED in SLE, underscoring its role in cardiovascular risk.
    • Introduces a potentially more accessible and clinically applicable method for ED assessment in SLE.
    • Suggests that improved ED diagnosis can aid in modifying existing diagnostic strategies for SLE patients.