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Rapid formulation screening with a Multipart Microscale Fluid bed Powder processor
Niina Kivikero1, Matti Murtomaa, Osmo Antikainen
1Industrial Pharmacy, University of Helsinki, Finland. niina.kivikero@helsinki.fi
Pharmaceutical Development and Technology
|April 15, 2010
Summary
This study demonstrates rapid, small-scale granulation using a miniaturized fluid bed processor and electrostatic atomization. The method efficiently produced varied granules, though analytical challenges for small batches remain.
Area of Science:
- Pharmaceutical Technology
- Process Engineering
Background:
- Early formulation screening is crucial for drug development.
- Miniaturized devices offer advantages for small-scale studies.
- Electrostatic atomization is a viable granulation technique.
Purpose of the Study:
- To evaluate a miniaturized fluid bed processor for early formulation screening.
- To investigate granule properties produced via electrostatic atomization.
- To assess the feasibility of rapid screening with limited material.
Main Methods:
- Granulation of eight batches using a Multipart Microscale Fluid bed Powder processor (MMFP) with electrostatic atomization.
- Use of acetylsalicylic acid as API and lactose, microcrystalline cellulose, and polyvinylpyrrolidone as excipients.
- Analysis of granule size distribution, friability, and compressibility; multivariate data analysis.
Main Results:
- Successful generation of granules with varying compositions using MMFP.
- Consistent process conditions yielded reliable and logical results.
- Acquisition of meaningful data from small material quantities.
Conclusions:
- The MMFP with electrostatic atomization enables rapid, small-scale formulation screening.
- The system is effective for generating diverse granules efficiently.
- Developing suitable analytical methods for small batches is a key challenge.
