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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Related Experiment Video

Updated: Jun 13, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

Magnesium and aging.

M Barbagallo1, L J Dominguez

  • 1Mario Barbagallo, MD Viale F Scaduto 6/c, 90144 Palermo, Italy. mabar@unipa.it

Current Pharmaceutical Design
|April 15, 2010
PubMed
Summary
This summary is machine-generated.

Magnesium (Mg) deficiency impairs mitochondrial energy production and antioxidant defenses, contributing to inflammation and oxidative stress in aging. Addressing Mg inadequacy is crucial for mitigating age-related diseases and improving healthspan.

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

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Last Updated: Jun 13, 2026

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles
14:02

Ex Vivo Assessment of Contractility, Fatigability and Alternans in Isolated Skeletal Muscles

Published on: November 1, 2012

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

  • Gerontology
  • Biochemistry
  • Cell Biology

Background:

  • Magnesium (Mg) is vital for cellular energy production (ATP synthesis) and antioxidant defense mechanisms.
  • Mg deficiency exacerbates oxidative stress and chronic inflammation, key factors in aging and age-related diseases.
  • Aging is frequently linked to Mg inadequacy, increasing susceptibility to chronic conditions like sarcopenia, diabetes, and cardiovascular disease.

Purpose of the Study:

  • To explore the age-related changes in magnesium metabolism and their consequences.
  • To discuss challenges in assessing magnesium status in aging populations.
  • To review evidence linking chronic Mg deficits to the interplay of inflammation and oxidative stress in aging.

Main Methods:

  • Literature review of studies on magnesium metabolism, aging, inflammation, and oxidative stress.
  • Analysis of the role of magnesium in mitochondrial function and antioxidant capacity.
  • Examination of the link between dietary and secondary magnesium deficits in the elderly.

Main Results:

  • Mg deficiency negatively impacts mitochondrial ATP production and reduces antioxidant capacity.
  • Chronic Mg deficit promotes excessive free radical production and low-grade inflammation.
  • Age-related Mg inadequacy is associated with muscle loss, immune dysfunction, and metabolic disorders.

Conclusions:

  • Age-related magnesium deficits represent a significant link between inflammation, oxidative stress, and the aging process.
  • Understanding Mg metabolism modifications with age is critical for addressing age-related diseases.
  • Targeting magnesium status may offer a therapeutic strategy for mitigating aging-associated pathologies.