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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Malignant otitis externa: case series.

T Ali¹, K Meade, S Anari

¹Department of Radiology, Freeman Hospital, Newcastle upon Tyne, UK.

The Journal of Laryngology and Otology

|April 15, 2010

Summary

This summary is machine-generated.

Malignant otitis externa cases showed higher cranial nerve palsy rates. All Pseudomonas aeruginosa strains remained sensitive to ciprofloxacin, contrary to emerging resistance concerns.

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Area of Science:

Otolaryngology
Infectious Diseases
Medical Microbiology

Background:

Investigating malignant otitis externa (MOE) epidemiology and ciprofloxacin resistance.
Assessing drug resistance patterns in MOE patient populations.
Addressing concerns about rising ciprofloxacin resistance.

Observation:

Retrospective review of 37 MOE cases (2000-2009) in a UK tertiary center.
Median patient age was 81 years; 51% had diabetes.
40% experienced facial nerve palsy, 24% multiple cranial nerve palsies.

Findings:

Pseudomonas aeruginosa identified in 54% of cases.
All P. aeruginosa isolates were sensitive to ciprofloxacin.
Higher cranial nerve palsy incidence noted compared to prior studies.

Implications:

Cranial nerve involvement in MOE may be more common than previously thought.
Local P. aeruginosa strains remain susceptible to ciprofloxacin, challenging resistance narratives.
This data informs treatment strategies for MOE, particularly regarding antibiotic choice.