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Updated: Jun 13, 2026
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Pathological study of radial sclerosing lesions]
Xiao-li Zhang1, Guang-zhi Yang, Hua-ye Ding
1Shanxi Medical University, Taiyuan, China.
Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|April 15, 2010
Summary
Radial sclerosing lesions of the breast exhibit distinct histological features that can be mistaken for cancer. Accurate differentiation from various breast carcinomas is crucial for correct diagnosis and patient management.
Area of Science:
- Breast pathology
- Sclerosing lesions
- Histopathology
Context:
- Radial sclerosing lesions (RSLs) are uncommon benign breast lesions.
- Distinguishing RSLs from malignant neoplasms is critical for appropriate patient care.
Purpose:
- To detail the pathological diagnostic features of RSLs.
- To outline differential diagnostic considerations for RSLs.
Summary:
- This study analyzed 44 cases of RSLs using morphological observation and immunohistochemistry.
- Key features include a radiating outline, central scar, and peripheral ductal/lobular proliferation, sometimes with metaplasia.
- Immunostaining confirmed myoepithelial cells around tubules and epithelial cell positivity for CK5/6.
- Misdiagnosis as carcinoma occurred in 13 of 31 consultation cases.
Impact:
- Highlights characteristic histological findings of RSLs.
- Emphasizes the importance of differentiating RSLs from ductal carcinoma in situ, lobular neoplasia, tubular carcinoma, and invasive ductal carcinoma.
