Mitochondrial calcium channels
Related Experiment Video
Updated: Jun 13, 2026

Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
Published on: April 27, 2018
1Department of Internal Medicine III, University of Cologne, Cologne, Germany. uta.hoppe@uni-koeln.de
Abstract:
Mitochondrial Ca(2+) handling plays an important role in energy production and various cellular signaling processes. Mitochondrial Ca(2+) uptake is regulated by the mitochondrial Ca(2+) uniporter (MCU), at least one non-MCU Ca(2+) channel and possibly a mitochondrial ryanodine receptor. Two distinct mechanisms mediate Ca(2+) outward transport, the Na(+)-dependent (mNCX) and the Na(+)-independent Ca(2+) efflux. In recent years we gained more insight into the regulation and function of these different Ca(2+) transport mechanisms. However, the precise physiological role and the molecular structure of all mitochondrial Ca(2+) transporters and channels still has to be determined.
More Related Videos
08:43Simultaneous Measurement of Mitochondrial Calcium and Mitochondrial Membrane Potential in Live Cells by Fluorescent Microscopy
Published on: January 24, 2017
13:42Multi-parameter Measurement of the Permeability Transition Pore Opening in Isolated Mouse Heart Mitochondria
Published on: September 7, 2012
Related Concept Videos
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Mitochondrial Membranes
Mitochondrial Membranes
The Inner Mitochondrial Membrane
Voltage-gated Ion Channels
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...