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Related Experiment Video

Updated: Jun 13, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Multiple and dependent scattering effects in Doppler optical coherence tomography.

J Kalkman¹, A V Bykov, D J Faber

¹Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands. j.kalkman@amc.nl

|April 15, 2010

Summary

This summary is machine-generated.

Doppler optical coherence tomography (OCT) reveals that multiple scattering in dense media like Intralipid causes signal attenuation and flow distortions. This study quantifies these effects, crucial for accurate turbid media imaging.

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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Area of Science:

Biomedical Optics
Medical Imaging
Fluid Dynamics

Background:

Doppler optical coherence tomography (OCT) images tissue morphology and blood flow.
Basic OCT relies on single scattering, but dense media exhibit multiple scattering.
Multiple scattering complicates OCT signal attenuation and Doppler flow measurements.

Purpose of the Study:

Investigate the impact of multiple and concentration-dependent scattering on OCT signal attenuation and Doppler flow.
Analyze Intralipid solutions with varying scattering strengths.
Compare OCT measurements with Monte Carlo simulations.

Main Methods:

Utilized Doppler optical coherence tomography (OCT) to image Intralipid solutions.
Varied Intralipid concentrations to alter scattering properties.
Performed Monte Carlo simulations for comparison.

Main Results:

Observed non-linear increase in OCT signal attenuation rate with Intralipid concentration.
Noted increasingly distorted Doppler OCT flow profiles at higher concentrations.
Found single scattering attenuation coefficient was 15% higher than measured OCT attenuation rate.

Conclusions:

Multiple scattering significantly affects OCT signal attenuation and flow profile accuracy in dense media.
Concentration-dependent scattering contributes to the non-linear behavior of the single scattering attenuation coefficient.
Accurate OCT analysis in turbid media requires accounting for multiple scattering effects.