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Updated: Jun 13, 2026
Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
Published on: October 17, 2016
A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived
Anthony Kim1, Mathieu Roy, Farhan Dadani
1Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute/Campbell Family Institute for Cancer Research, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
Abstract:
Measurement of tissue optical absorption and (transport) reduced scattering coefficients (mu(a) and mu(s)', respectively) is fundamental to many applications of light in medicine and biology. We report a handheld fiberoptic probe to determine these coefficients by measuring the diffuse reflectance at multiple source-collector distances, which allows for a larger dynamic range than a single source-collector separation. Diffusion theory and a priori knowledge of the spectral shape of mu(a) and mu(s)' are used in a forward model of the diffuse reflectance. The dynamic range and accuracy of this method were evaluated using Monte Carlo simulations, phantom experiments and tissues in vivo.
