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Development and evaluation of a chloramphenicol hypertonic ophthalmic solution
A V Jithan1, C Krishna Mohan, M Vimaladevi
1Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, India.
Indian Journal of Pharmaceutical Sciences
|April 15, 2010
Summary
This study developed a stable, hypertonic chloramphenicol eye drop solution using cosolvency. This novel formulation enhances chloramphenicol solubility and stability for treating ocular edema.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Physical Chemistry
Background:
- Hypertonic ophthalmic solutions are crucial for managing ocular diseases characterized by edema.
- Chloramphenicol is an antibiotic used to treat bacterial eye infections, but its formulation can be challenging.
Purpose of the Study:
- To develop a stable, hypertonic ophthalmic solution of chloramphenicol.
- To enhance the solubility and stability of chloramphenicol using cosolvency principles.
Main Methods:
- Developed chloramphenicol hypertonic ophthalmic solutions utilizing cosolvency and dielectric constant concepts.
- Employed polyethylene glycol 300 (PEG 300) and glycerol as cosolvents.
- Determined solubility curves and evaluated physical parameters and accelerated stability of selected formulations.
Main Results:
- The cosolvency technique successfully enhanced both the solubility and stability of chloramphenicol.
- The developed ophthalmic solutions were confirmed to be hypertonic.
- Accelerated stability studies indicated that chloramphenicol remained stable within the tested formulations.
Conclusions:
- Cosolvency is an effective strategy for improving chloramphenicol solubility and stability in ophthalmic preparations.
- The developed hypertonic chloramphenicol ophthalmic solution shows promise for treating ocular edema.
