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Optimization of fast dissolving etoricoxib tablets prepared by sublimation technique
1Department of Pharmaceutics and Pharmaceutical Technology, Shri Sarvajanik Pharmacy College, Mehsana - 384 001, India.
Indian Journal of Pharmaceutical Sciences
|April 15, 2010
Summary
This study developed fast dissolving etoricoxib tablets using menthol sublimation. Optimized formulations with higher crospovidone and menthol showed rapid disintegration and improved drug dissolution compared to conventional tablets.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Fast dissolving tablets (FDTs) offer improved patient compliance and faster onset of action.
- Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) requiring effective drug delivery.
Purpose of the Study:
- To develop and optimize fast dissolving tablets (FDTs) of etoricoxib.
- To investigate the effect of menthol and crospovidone on tablet properties and dissolution.
Main Methods:
- Wet granulation technique was employed to prepare etoricoxib granules.
- Menthol was sublimed from granules or compressed tablets using vacuum.
- A 3(2) full factorial design was used to optimize formulation variables.
- Tablets were evaluated for friability, disintegration time, and drug dissolution.
Main Results:
- Sublimation of menthol from tablets resulted in significantly faster disintegration than from granules.
- Higher concentrations of crospovidone and an optimal amount of menthol were crucial for FDTs.
- The optimized FDTs exhibited enhanced etoricoxib dissolution compared to marketed formulations.
Conclusions:
- Fast dissolving etoricoxib tablets can be effectively prepared using menthol sublimation.
- This technique improves drug dissolution and offers a promising approach for NSAID delivery.
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