Related Experiment Video
Updated: Jun 13, 2026
14:20
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Novel colon targeted drug delivery system using natural polymers
V Ravi1, T M Pramod Kumar, Siddaramaiah
1Department of Pharmaceutics, J. S. S College of Pharmacy, S. S Nagar, Mysore - 570 015, India.
Indian Journal of Pharmaceutical Sciences
|April 15, 2010
Summary
This study developed a novel colon-targeted tablet using pectin, inulin, and shellac. The formulation effectively delivered drugs in the colon, showing potential for targeted drug delivery systems.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Colonic Drug Targeting
Background:
- Colon targeted drug delivery aims to improve therapeutic efficacy and reduce systemic side effects.
- Conventional oral formulations often fail to reach the colon due to drug release in the upper gastrointestinal tract.
Purpose of the Study:
- To develop and evaluate a novel colon-targeted tablet formulation using pectin as a carrier.
- To assess the suitability of inulin and shellac as coating materials for colon targeting.
Main Methods:
- Tablets were formulated using pectin as a carrier with diltiazem HCl and indomethacin as model drugs.
- Tablets were coated sequentially with inulin and shellac.
- In vitro release studies were conducted in simulated gastric, small intestinal, and colonic environments.
Main Results:
- The inulin-shellac coating effectively prevented premature drug release in simulated stomach and small intestine conditions.
- Maximum drug release was observed in the simulated colonic fluid, confirming colon targeting.
- The formulation demonstrated successful drug release for both water-soluble and water-insoluble model drugs.
Conclusions:
- Pectin, inulin, and shellac are effective components for developing colon-targeted drug delivery systems.
- This novel formulation holds promise for targeted delivery of drugs to the colon, enhancing therapeutic outcomes.
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:27Drug Delivery Systems: Different Types
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...