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Updated: Jun 13, 2026

Antibody Profiling by Luciferase Immunoprecipitation Systems (LIPS)
Published on: October 7, 2009
[Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations]
A Tincani1, C Casu, S Cartella
1Servizio di Reumatologia e Immunologia Clinica, Cattedra di Reumatologia, Università degli Studi di Brescia, Spedali Civili, Brescia, Italia. tincani@bresciareumatologia.it
Abstract:
Antiphospholipid antibodies (aPL) represent a heterogeneous group of antibodies that recognize various antigenic targets including beta2 glycoprotein I (beta2GPI), prothrombin (PT), activated protein C, tissue plasminogen activator, plasmin and annexin A2. The most commonly used tests to detect aPL are: lupus anticoagulant (LAC), a functional coagulation assay, anticardiolipin antibody (aCL) and anti-beta2GPI antibody (anti-beta2GPI), which are enzyme-linked immunoassay (ELISA). Clinically aPL are associated with thrombosis and/or with pregnancy morbidity. Apparently aPL alone are unable to induce thrombotic manifestations, but they increase the risk of vascular events that can occur in the presence of another thrombophilic condition; on the other hand obstetrical manifestations were shown to be associated not only to thrombosis but mainly to a direct antibody effect on the trophoblast.
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