Related Experiment Video
Updated: Jun 13, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Angioplasty and stenting for the occluded internal carotid artery
Xuanye Yue1,2, Gelin Xu, Wenhua Liu
1Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, 305# East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China.
Insights
Angioplasty and stenting show promise for treating carotid artery occlusion, a cause of stroke. While generally safe, further research is needed to confirm long-term efficacy and safety.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Neurology
Background:
- Carotid artery occlusion can lead to severe neurological events like ischemic stroke.
- Symptomatic carotid artery occlusion presents a significant clinical challenge.
- Traditional treatments may carry risks, prompting investigation into endovascular options.
Purpose of the Study:
- To evaluate the feasibility and effectiveness of angioplasty and stenting.
- To assess outcomes in patients with symptomatic total carotid artery occlusion.
- To identify potential complications and long-term results of the procedure.
Main Methods:
- Retrospective review of 17 patients with total carotid artery occlusion.
- Patients underwent angioplasty and stenting between December 2004 and June 2009.
- Prospective follow-up including clinical assessment and angiography.
Main Results:
- Technical success rate of 70% (12 out of 17 patients).
- No procedure-related complications were observed.
- One patient developed in-stent stenosis (11.1%) during follow-up; one died from myocardial infarction, another had a minor stroke.
Conclusions:
- Angioplasty and stenting represent a potential alternative therapy for symptomatic carotid artery occlusion.
- The procedure demonstrated feasibility with acceptable short-term outcomes.
- Further studies are warranted to establish the definitive safety and efficacy profile.
Abstract:
To investigate the feasibility and efficacy of angioplasty and stenting for symptomatic occlusion of carotid artery. From December 2004 to June 2009, 17 patients with progressive or reoccurred ischemic stroke or repeated transient ischemic attack resulted from the total occluded carotid artery underwent angioplasty and stenting were reviewed. All patients with successful procedure were followed up. Clinic and angiography data were documented prospectively. The median time from symptoms onset to procedure was 23 days (range 3-94 days). Twelve of the 17 patients (70%) were obtained technique success. Eight patients were observed the collapse of internal carotid artery between occluded location to origin of ophthalmic artery after the occlusion was patent. Two patients had clots which were solved with urokinase. The collapsed internal carotid artery was improved markedly in the compute tomography angiograph 7 days after the procedure. No any complications related procedures occurred. One patient died from myocardial infarct and one suffered from ischemic minor stroke in brainstem for a median follow-up of 346.5 days. One of 9 patients (11.1%) was observed in-stent stenosis in the follow-up angiography. Angioplasty and stenting was a potential alternative therapy for symptomatic occlusion of carotid artery. Further study is required to determine the safety of this treatment.
Related Concept Videos
Coronary Artery Disease V: Interprofessional Care
Peripheral Artery Disease III: Interprofessional Care
Aneurysm III: Interprofessional Care
Angina IV: Management
Acute Coronary Syndrome IV: Interprofessional Care
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
