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[The effect of an extract from Cochlospermum angolense ("Burututu") on Plasmodium berghei in the mouse malaria
W Presber1, D K Herrmann, B Hegenscheid
1Institut für Medizinische Mikrobiologie des Bereiches Medizin (Charité), Humboldt-Universität zu Berlin, BRD.
Angewandte Parasitologie
|February 1, 1991
Abstract:
Often existing cross-resistance to structure analogous antimalarials causes the need to find new active compounds against malaria parasites. For this purpose the traditional medicine of tropical countries has proved to be a treasury. A root extract of Cochlospermum angolense showed in vitro a remarkable activity against Plasmodium berghei in the DNA synthesis measurement with 3H-labelled hypoxanthine. This effect could be reproduced under in vivo conditions with the "4-day suppressive test" of rodent malaria.