Toward effective long-term prevention of thromboembolism: novel oral anticoagulant delivery systems

Area of Science:

• Pharmacology
• Biomedical Engineering
• Drug Delivery Systems

Background:

• Thromboembolism prevention remains a challenge despite extensive research on oral anticoagulants.
• Novel oral drug delivery systems (DDSs) offer a potential avenue for enhancing anticoagulant therapy.
• Understanding drug absorption from the gastrointestinal tract is crucial for DDS development.

Purpose of the Study:

• To review clinical trials of oral anticoagulant DDSs.
• To describe promising preclinical anticoagulant DDSs.
• To explore the potential of novel DDSs in improving anticoagulant therapy.

Main Methods:

• Review of clinical trials involving anticoagulants in oral DDSs.
• Description of selected preclinical examples of novel anticoagulant DDSs.
• Inclusion of background information on DDS and gastrointestinal drug absorption.

Main Results:

• Three main approaches using specific carriers are currently in clinical investigation for oral anticoagulant DDSs.
• Preclinical research shows diverse DDS possibilities, including nanotechnology, for oral anticoagulant delivery.
• Clinical translation of promising preclinical DDS strategies is warranted.

Conclusions:

• Novel oral DDSs represent a significant opportunity to improve long-term thromboembolism prevention.
• Continued investigation into both clinical and preclinical anticoagulant DDSs is essential.
• The development of advanced DDSs could overcome current limitations in anticoagulant therapy.