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Pathogenesis of retinal dystrophy in the Royal College of Surgeons rat
F H Davidorf1, D B Mendlovic, D W Bowyer
1Department of Ophthalmology, Ohio State University, Columbus 43210.
Annals of Ophthalmology
|March 1, 1991
Abstract:
The Royal College of Surgeons (RCS) rat is an animal with genetically transmitted progressive retinal dystrophy. We compared histopathologically the RCS rat retina with normal age-matched control retinas (Long-Evans rats) using light and scanning electron microscopy. Retinal degeneration begins with alteration of the rod outer segments. There is a progressive involvement of the entire retina, with all layers affected by 45 days. The three-dimensional view obtained with scanning electron microscopy provides another perspective on the pathogenetic changes of the RCS retina.