Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning-based quantification of knee effusion-synovitis volume on MRI - Technique development and validation.

Osteoarthritis and cartilage·2026
Same author

Elevated Serum CXCL9 Levels Are Associated with Greater Frailty Risk in Older Women.

Endocrinology and metabolism (Seoul, Korea)·2026
Same author

Association between central obesity and MRI-based biomarkers of knee osteoarthritis independent of BMI: A cross-sectional study from the Osteoarthritis Initiative database.

Osteoarthritis and cartilage open·2026
Same author

Sex- and site-specific associations between hemoglobin levels and cortical bone structure and microarchitecture in older adults.

Bone·2026
Same author

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA).

medRxiv : the preprint server for health sciences·2026
Same author

Greater recalled pain and movement-evoked pain are associated with longer 400-m walk and repeat stair climb timein older adults: the study of muscle, mobility, and aging.

GeroScience·2026
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Glucocorticoid-induced bone fragility.

Nancy E Lane1, Wei Yao

  • 1Department of Medicine, University of California, Sacramento, California, USA. nelane@ucdavis.edu

Annals of the New York Academy of Sciences
|April 16, 2010
PubMed
Summary
This summary is machine-generated.

Glucocorticoid (GC) use causes rapid bone loss and fracture risk by increasing bone remodeling and altering osteocyte metabolism. This leads to reduced bone strength and increased fragility.

More Related Videos

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
08:36

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Published on: November 30, 2017

Related Experiment Videos

Last Updated: Jun 13, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
08:36

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Published on: November 30, 2017

Area of Science:

  • Bone biology
  • Endocrinology
  • Pharmacology

Background:

  • Glucocorticoid (GC) therapy is associated with significant bone loss and increased fracture risk.
  • The mechanisms underlying GC-induced bone fragility are complex and multifactorial.

Purpose of the Study:

  • To elucidate the multifaceted effects of glucocorticoids on bone remodeling and osteocyte metabolism.
  • To understand the impact of GCs on localized bone strength.

Main Methods:

  • Review of mechanisms by which GCs affect bone remodeling, including hormonal changes and effects on bone cells.
  • Examination of GC-induced alterations in osteocyte metabolism and bone material properties in a mouse model.

Main Results:

  • GCs increase bone remodeling by reducing gonadal hormones, increasing parathyroid hormone (PTH), and modulating osteoclast and osteoblast activity.
  • GCs alter osteocyte metabolism, leading to larger lacunae, periolacunar demineralization, and reduced elastic modulus in bone.

Conclusions:

  • Glucocorticoid-induced bone fragility is a complex outcome of altered bone remodeling and osteocyte dysfunction.
  • Further research is needed to fully understand GC-mediated changes in osteocyte metabolism and their contribution to reduced bone strength.