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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 13, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Depression and bone mass.

Itai A Bab1, Raz Yirmiya

  • 1Bone Laboratory, The Hebrew University of Jerusalem, Jerusalem, Israel. babi@cc.huji.ac.il

Annals of the New York Academy of Sciences
|April 16, 2010
PubMed
Summary
This summary is machine-generated.

Depression is linked to lower bone mineral density (BMD), especially in women. This study confirms depression as a risk factor for osteoporosis, impacting bone loss via the sympathetic nervous system.

Related Experiment Videos

Last Updated: Jun 13, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

  • Neuroscience
  • Endocrinology
  • Orthopedics

Background:

  • Low bone mineral density (BMD) prevalence is noted in patients with depressive disorders.
  • Depression is not yet officially recognized as a risk factor for osteoporosis.

Purpose of the Study:

  • To investigate the association between depression and BMD.
  • To explore the causal relationship between depressive behavior and bone loss.
  • To identify mechanisms underlying depression-induced bone loss.

Main Methods:

  • Meta-analysis comparing BMD in depressed versus nondepressed individuals.
  • Utilizing a mouse model to establish a causal link between depression and bone loss.
  • Measuring skeletal norepinephrine and serum corticosterone levels.

Main Results:

  • Depressed individuals exhibit lower BMD compared to nondepressed individuals.
  • The association between depression and BMD is more pronounced in women, particularly premenopausal women.
  • Psychiatrically diagnosed major depression in women is linked to significantly low BMD.
  • Depression-induced bone loss in mice involves increased skeletal norepinephrine and serum corticosterone.
  • Beta-blockers prevented bone loss in mice but not depressive behavior.

Conclusions:

  • Depression is a significant risk factor for low BMD and osteoporosis.
  • Depression causes bone loss through sympathetic nervous system stimulation.
  • Targeting the sympathetic nervous system may offer therapeutic strategies for depression-related bone loss.