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Updated: Jun 13, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract
Dagmar Simon1, Andrew Wardlaw, Marc E Rothenberg
1Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Abstract:
Eosinophils are multifunctional leukocytes that increase in various tissues in patients with a variety of disorders. Locally, they can be involved in the initiation and propagation of diverse inflammatory responses. In this review the clinical association of eosinophils with diseases of the skin, lung, and gastrointestinal tract is summarized. An approach to determining the causal role of eosinophils in these diseases is presented. Recent findings concerning molecular diagnosis, cause, and treatment are discussed.
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