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Related Experiment Video

Updated: Jun 13, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

A new life for bile acids.

Peter L M Jansen¹

¹Department of Gastrointestinal and Liver Disease, Academic Medical Center, Amsterdam, The Netherlands. p.l.jansen@amc.uva.nl

Journal of Hepatology

|April 16, 2010

Summary

TGR5 activation by bile acids boosts energy expenditure and reduces obesity. This receptor signaling enhances glucagon-like peptide-1 (GLP-1) release, improving metabolic function and glucose tolerance in obese mice.

Area of Science:

Metabolic Research
Endocrinology
G protein-coupled receptor signaling

Background:

TGR5, a G protein-coupled receptor in brown adipose tissue and muscle, increases energy expenditure and combats diet-induced obesity.
Activation of TGR5 by bile acids is a key regulator of metabolic homeostasis.

Discussion:

TGR5 signaling stimulates intestinal glucagon-like peptide-1 (GLP-1) release, a crucial incretin hormone.
This GLP-1 induction improves liver and pancreatic function and enhances glucose tolerance in obese mouse models.

Key Insights:

Pharmacological and genetic studies demonstrate TGR5's role in regulating GLP-1 secretion in vivo.
The TGR5 agonist 6alpha-ethyl-23(S)-methyl-cholic acid (EMCA) increases intracellular ATP/ADP ratio and calcium mobilization in enteroendocrine cells, leading to GLP-1 release.

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Last Updated: Jun 13, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Outlook:

Targeting TGR5 represents a potential therapeutic strategy for diabesity and related metabolic disorders.
Further research into TGR5 agonists could lead to novel incretin-based treatments.