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Lysozyme overexpression in fundic gland polyps

Carlos A Rubio1

  • 1Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden. Carlos.Rubio@ki.se

Anticancer Research
|April 16, 2010
PubMed
Abstract

Insights

Fundic gland polyps (FGPs) show high lysozyme expression, potentially explaining why Helicobacter pylori (Hp) rarely proliferates in these patients. This natural defense mechanism warrants further investigation.

Area of Science:

  • Gastroenterology
  • Pathology
  • Microbiology

Background:

  • Helicobacter pylori (Hp) infection is common, but its proliferation is notably rare in patients with fundic gland polyps (FGPs).
  • FGPs exhibit expression of lysozyme, a key component of the innate immune system involved in combating microbial infections.

Purpose of the Study:

  • To investigate and quantify the expression levels of lysozyme in fundic gland polyps (FGPs).
  • To correlate lysozyme expression patterns with the presence or absence of Helicobacter pylori (Hp) infection.

Main Methods:

  • Analysis of 153 gastric biopsies, including FGPs, normal mucosa, Hp-induced gastritis, and non-Hp gastritis.
  • Immunohistochemical staining using anti-lysozyme (muramidase) antibodies to assess lysozyme distribution and intensity.

Main Results:

  • Lysozyme expression was observed in various gastric tissues, with marked expression in neck glands of normal mucosa and gastritis.
  • A higher ratio of lysozyme in neck glands compared to foveoli was noted in non-Hp gastritis and Hp-gastritis.
  • FGPs demonstrated significant lysozyme expression in surface epithelium, foveolar pits, and cyst-lining cells.

Conclusions:

  • The elevated lysozyme production in the epithelium of FGPs may serve as a protective mechanism against Helicobacter pylori proliferation.
  • While lysozyme in gastritis may not be sufficient for bacterial eradication, its overproduction in FGPs offers a potential explanation for the low incidence of Hp infection in these polyps.

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