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NT-proBNP concentrations in mountain marathoners.

Giuseppe Banfi1, Giuseppe Lippi, Daniele Susta

  • 1Institute R. Galeazzi, IRCCS, I- 20161 Milan, Italy.

Journal of Strength and Conditioning Research
|April 16, 2010
PubMed
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N-terminal proB-type natriuretic peptide (NT-proBNP) levels are low at rest in athletes but increase after strenuous exercise like marathons. This physiological increase highlights NT-proBNP

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Area of Science:

  • Cardiology
  • Sports Medicine
  • Biochemistry

Background:

  • N-terminal proB-type natriuretic peptide (NT-proBNP) is a biomarker for myocardial wall stress and heart pathologies.
  • Strenuous exercise, such as marathon running, can induce myocardial stress and potential cardiac dysfunction.
  • Previous alerts noted cardiac dysfunction signs in recreational athletes during marathons, necessitating further investigation.

Purpose of the Study:

  • To investigate the behavior of NT-proBNP levels in mountain marathoners before and after a race.
  • To compare NT-proBNP concentrations in marathoners with resting controls and athletes from other disciplines.
  • To assess the physiological significance of NT-proBNP increase following strenuous physical exertion.

Main Methods:

  • Studied 15 mountain marathoners, measuring NT-proBNP concentrations before and after a marathon race.
  • Compared marathoner NT-proBNP levels to those of resting controls and professional soccer/rugby players.
  • Monitored troponin I levels as an indicator of heart effort.

Main Results:

  • Marathoners exhibited lower resting NT-proBNP than controls, similar to other professional athletes.
  • NT-proBNP concentrations significantly increased after the marathon race.
  • The post-exercise increase in NT-proBNP and troponin I suggests physiological adaptation to strenuous exercise.

Conclusions:

  • The increase in NT-proBNP after marathon running is a physiological response to heavy cardiac effort.
  • NT-proBNP levels in marathoners are comparable to athletes in other sports, even at high altitudes.
  • NT-proBNP may serve as a valuable screening tool for identifying potential cardiac issues in marathoners, aiding in preventing sudden cardiac death.