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Fesoterodine fumarate
A Gomelsky1, Roger R Dmochowski
1Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Drugs of Today (Barcelona, Spain : 1998)
|April 16, 2010
Summary
Fesoterodine fumarate effectively treats overactive bladder (OAB) by reducing incontinence episodes and improving quality of life. This medication
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder (OAB) significantly impacts patient quality of life.
- Muscarinic antagonists are primary oral treatments for OAB.
Purpose of the Study:
- To evaluate the efficacy and safety of fesoterodine fumarate for OAB treatment.
Main Methods:
- Two Phase III clinical studies were conducted.
- Patients received fesoterodine fumarate or placebo.
- Outcomes measured included urgency, urge urinary incontinence (UUI) episodes, and quality of life indices.
Main Results:
- Fesoterodine fumarate significantly reduced urgency and UUI episodes compared to placebo.
- 60% of patients on fesoterodine reported no UUI episodes.
- Quality of life indices showed significant improvement with fesoterodine treatment.
Conclusions:
- Fesoterodine fumarate is an effective treatment for OAB.
- The active metabolite, 5-hydroxymethyl tolterodine, mediates antimuscarinic effects.
- Adverse events like dry mouth and constipation were dose-related but rarely led to discontinuation.
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