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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Clinical aspects of temporal arteritis: course variations up to fatal complications]
A Brüggemann1, K Holl-Ulrich, M Müller
1Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland, anne.brueggemann@uk-sh.de.
Background:
Arteritis temporalis (AT) shows a variable course of the disease and may lead to transient or permanent visual loss.
Patients And Methods:
In a retrospective consecutive case series 66 patients with suspected AT were followed up of which 65 underwent arterial biopsy. Symptoms, therapy and complications were followed up.
Results:
Of the patients 32 (49.2%) revealed a positive histological finding in unilateral (55.4%) or bilateral (44.6%) biopsy. Of these 3 (9.4%) suffered a severe or fatal outcome: two with extensive ischemia of the vertebrobasilar system (one fatal) and one patient died due to acute pancreatitis, a rare side effect of systemic steroid therapy.
Conclusion:
When systemically apparent, arteritis temporalis can progress to reduction of general health, cerebral ischemia and organ infarction. Therefore, AT is a serious disease requiring interdisciplinary, immediate diagnostics and prompt therapy.
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