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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jun 13, 2026

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis.

Jing Jiang1, Xianyuan Wang, Xinjing Wang

  • 1School of Nursing, Third Military Medical University, Chongqing, China.

Journal of Clinical Immunology
|April 16, 2010
PubMed
Summary

Reduced CD27 expression on CD4 T cells indicates persistent active tuberculosis (TB). This finding suggests CD27+ T cells could serve as a key biomarker for identifying individuals with persistent pulmonary TB.

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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

Area of Science:

  • Immunology
  • Infectious Diseases
  • Cell Biology

Background:

  • CD27, a tumor necrosis factor receptor family member, is crucial for T cell immunity.
  • Understanding T cell responses is vital for diagnosing and managing infectious diseases like tuberculosis.

Purpose of the Study:

  • To investigate the association between CD27 expression on mycobacterial antigen-specific CD4+ T cells and pulmonary tuberculosis (TB).
  • To evaluate CD27 as a potential immunological marker for persistent active TB.

Main Methods:

  • Identification of mycobacterial antigen-specific CD4+ T cells using CD154 expression.
  • Analysis of CD27 expression on these T cells via flow cytometry.

Main Results:

  • Patients with bacterial culture-positive pulmonary TB showed significantly lower CD27 expression on antigen-specific CD4+ T cells compared to controls.
  • Persistent active TB patients had markedly lower percentages of CD27+ antigen-specific CD4+ T cells than new TB patients and healthy controls.
  • Logistic regression revealed that a low percentage of CD27+ T cells strongly correlated with persistent active TB (OR=19.6).

Conclusions:

  • The frequency of CD27+ antigen-specific CD4+ T cells can serve as an immunological marker for persistent active TB.
  • This marker may aid in distinguishing persistent disease forms and guiding treatment strategies.