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TRPM5 regulates glucose-stimulated insulin secretion

Lili R Brixel1, Mahealani K Monteilh-Zoller, Claudia S Ingenbrandt

  • 1Centre for Paediatrics and Adolescent Medicine, University Medical Centre of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 63, 55131 Mainz, Germany.

Pflugers Archiv : European Journal of Physiology
|April 16, 2010
PubMed
Summary

Transient Receptor Potential Melastatin 5 (TRPM5) is crucial for glucose-stimulated insulin secretion. Mice lacking TRPM5 show impaired insulin release and elevated blood glucose, suggesting a role in type 2 diabetes.

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