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The raputindoles: novel cyclopentyl bisindole alkaloids from Raputia simulans

Konstantina Vougogiannopoulou1, Nikolas Fokialakis, Nektarios Aligiannis

  • 1Division of Pharmacognosy and Natural Products Chemistry, School of Pharmacy, University of Athens, Panepistimioupoli Zografou, Athens, Greece.

Organic Letters
|April 17, 2010
PubMed

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The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...