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Updated: Jun 13, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
ZBTB7 overexpression contributes to malignancy in breast cancer
Hongyan Qu1, Danni Qu, Fuhui Chen
1Department of Abdominal Surgery, The Tumor Hospital of Harbin Medical University, Harbin 150081, China. quhongyan-haerbin@163.com
Abstract:
ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZBTB7 expression levels were significantly correlated with histological grade (p = .023) and marginally inversely correlated with the presence of estrogen receptors (p = .053); its overexpression significantly predicted shorter recurrence-free survival (p = .033). Our results showed that ZBTB7 might be implicated in breast cancer development and may serve as a promising prognostic marker.
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