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The preparation and properties of bromoacetylphosphonic acid
1Department of Biochemistry, University of Cambridge, U.K.
The Biochemical Journal
|May 1, 1991
Abstract:
Bromoacetylphosphonic acid, Br-CH2-CO-PO3H2, was made by brominating dimethyl acetylphosphonate and de-esterifying with HBr. It proves to be a powerful alkylating agent, reacting rapidly with GSH, with a rate constant of about 6M(-1).s(-1) at pH6.