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Related Experiment Video

Updated: Jun 13, 2026

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Baculovirus as vaccine vectors.

Selvaraj Madhan1, Mookkan Prabakaran, Jimmy Kwang

  • 1Animal Health Biotechnology, Temasek Life Science Laboratory, 1 Research Link, National University of Singapore, Singapore.

Current Gene Therapy
|April 17, 2010
PubMed
Summary

Baculovirus, a non-human viral vector, offers a promising alternative for vaccine development due to its safety and immune-stimulating properties. This novel approach bypasses issues like pre-existing immunity, paving the way for next-generation vaccines.

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Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Viral vectors derived from human viruses face challenges like pre-existing immunity and toxicity.
  • Baculovirus presents a novel, non-human viral vector with potential for vaccine development.

Purpose of the Study:

  • To explore the potential of baculovirus as a safe and effective vaccine vector.
  • To investigate baculovirus-mediated immune responses for next-generation vaccine strategies.

Main Methods:

  • Development of recombinant envelope-modified baculovirus with shuttle promoters for in vivo transduction.
  • Administration via intranasal or oral routes to induce systemic and mucosal immune responses in animal models.

Main Results:

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Production and Purification of Baculovirus for Gene Therapy Application
06:11

Production and Purification of Baculovirus for Gene Therapy Application

Published on: April 9, 2018

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System
12:18

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System

Published on: November 6, 2013

Related Experiment Videos

Last Updated: Jun 13, 2026

Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

Production and Purification of Baculovirus for Gene Therapy Application
06:11

Production and Purification of Baculovirus for Gene Therapy Application

Published on: April 9, 2018

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System
12:18

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System

Published on: November 6, 2013

  • Baculovirus demonstrates broad tissue tropism and an improved safety profile.
  • Recombinant baculovirus shows promising results in animal models for inducing immune responses.
  • Intranasal or oral administration effectively elicits systemic and mucosal immunity.

    • Conclusions:

    • Baculovirus is a viable candidate for next-generation vaccine vector development.
    • Further research into baculovirus biology and host interactions will support its clinical application.