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Inhibition of myoblast differentiation by lack of zinc
L Petrie1, J K Chesters, M Franklin
1Biochemistry Division, Rowett Research Institute, Bucksburn, Aberdeen, U.K.
The Biochemical Journal
|May 15, 1991
Abstract:
The impact of restricted zinc availability on myoblast differentiation was investigated. Lack of zinc prevented myoblast fusion and the increase in muscle-specific creatine kinase activity. The depression of activity of creatine kinase in the zinc-deficient cultures was accompanied by a similar decrease in the concentration of creatine kinase mRNA and was apparent even when fusion of the myoblasts was inhibited by cytochalasin B. Thus zinc appears to be necessary for the expression of creatine kinase during myoblast differentiation.