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Updated: Jun 13, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Diabetes and weight management.

David C W Lau¹

¹Julia McFarlane Diabetes Research Centre, University of Calgary, Alberta, Canada. dcwlau@ucalgary.ca

Primary Care Diabetes

|April 17, 2010

Summary

Losing 5-10% of body weight significantly improves diabetes control. Insulin detemir offers an effective basal insulin option with less associated weight gain compared to other insulins, aiding diabetes management.

Area of Science:

Endocrinology
Metabolic Diseases
Pharmacology

Background:

Diabetes mellitus is a major global non-communicable chronic disease, exacerbated by the obesity epidemic.
Weight management is crucial for effective diabetes control, with 5-10% weight loss improving glycemic, lipid, and blood pressure levels.
Basal insulin therapy is a key component in managing type 2 diabetes.

Purpose of the Study:

To evaluate the efficacy and weight profile of insulin detemir in type 2 diabetes management.
To compare insulin detemir with other basal insulin options (NPH, glargine) regarding weight changes.
To assess the role of insulin detemir in patients also utilizing lifestyle interventions and oral anti-diabetic agents.

Main Methods:

Comparative analysis of clinical trial data for insulin detemir, NPH, and insulin glargine.

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Assessment of glycemic control (blood sugar levels) and weight changes in patients with type 2 diabetes.

Review of studies involving patients on lifestyle interventions and oral anti-diabetic agents requiring basal insulin.

Main Results:

Insulin detemir demonstrated efficacy in improving glycemic control.
Insulin detemir was associated with less weight gain compared to insulin NPH and insulin glargine.
A modest weight loss of 5-10% led to significant improvements in metabolic parameters.

Conclusions:

Insulin detemir is an effective basal insulin analogue for type 2 diabetes management.
Its favorable weight profile makes it a valuable option, particularly in the context of the obesity epidemic.
Once-daily insulin detemir can be considered for patients with type 2 diabetes on existing therapies who need insulin introduction.