Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apolipoprotein B upstream suppressor site: identification of an element which can decrease apolipoprotein B

R S Ross1, A C Li, J M Hoeg

  • 1Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Biochemical and Biophysical Research Communications
|May 15, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis on pathogenetic characteristics of newfound pneumoconiosis in Jinan, 2006 to 2014].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2016
Same author

Use of mouse models to evaluate roles of nuclear receptors and their ligands in the pathogenesis and treatment of atherosclerosis.

Current drug targets·2008
Same author

Regulation and intracellular trafficking of the ABCA1 transporter.

Journal of lipid research·2001
Same author

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice.

The Journal of clinical investigation·2001
Same author

Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

American journal of human genetics·2001
Same author

MR virtual angioscopy of thoracic aortic atherosclerosis in homozygous familial hypercholesterolemia.

Journal of computer assisted tomography·2001
Same journal

A transferrin receptor-based vector enables robust Type-II membrane protein display on mammalian cells.

Biochemical and biophysical research communications·2026
Same journal

NAT10-mediated RNA N4-acetylation promotes intestinal fibroblast senescence via DHRS2.

Biochemical and biophysical research communications·2026
Same journal

Deciphering potent MPL activation by the fucose-binding lectin thrombocorticin.

Biochemical and biophysical research communications·2026
Same journal

Mitochondrial genome alterations in cancer: From mutations and epigenetics to targeted therapiesack.

Biochemical and biophysical research communications·2026
Same journal

GPC3 chimeric antigen receptor (CAR)-NK cells combined with Enoblituzumab enhance the anti-tumor efficacy against hepatocellular carcinoma.

Biochemical and biophysical research communications·2026
Same journal

A miR-382-5p-PORCN axis modulates endogenous Wnt signaling during palatal development.

Biochemical and biophysical research communications·2026
See all related articles

Researchers discovered a new gene region, the apoB upstream suppressor site (aBUSS), that controls apolipoprotein B (apoB) production. This finding is crucial for understanding and potentially treating coronary atherosclerosis by regulating apoB levels.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Science

Background:

  • Elevated plasma apolipoprotein B (apoB) levels are linked to premature coronary atherosclerosis.
  • Understanding the regulation of apoB gene transcription is vital for cardiovascular health.

Purpose of the Study:

  • To identify and characterize regulatory elements within the apoB gene.
  • To investigate mechanisms controlling apoB gene transcription.

Main Methods:

  • Identification of a specific DNA domain within the apoB gene.
  • Analysis of trans-acting factor binding to this domain.
  • Mutagenesis studies to assess transcriptional activity.

Main Results:

  • A novel regulatory region, termed apoB upstream suppressor site (aBUSS), was identified.

Related Experiment Videos

  • This region binds cell-specific trans-activating factors, named apoB repressor proteins (ARP).
  • Mutagenesis of aBUSS led to increased apoB transcriptional activity.

    • Conclusions:

    • aBUSS and ARP are key players in the negative transcriptional modulation of the apoB gene.
    • These elements offer potential targets for therapeutic intervention in conditions associated with elevated apoB.