Related Experiment Video

Updated: Jun 13, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells

Thi Lien-Anh Nguyen1, Marnie Goodwin Wilson, John Hiscott

  • 1Molecular Oncology Group, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, Quebec, Canada H3T 1E2.

Cytokine & Growth Factor Reviews
|April 17, 2010
PubMed

Insights

Combining oncolytic viruses (OVs) with histone deacetylase inhibitors (HDIs) shows synergistic effects, enhancing cancer cell killing. This combination therapy offers a promising strategy beyond standalone treatments for cancer.

Area of Science:

  • Oncology
  • Virology
  • Epigenetics

Background:

  • Oncolytic viruses (OVs) show therapeutic potential but are unlikely to be effective as standalone treatments.
  • Histone deacetylase inhibitors (HDIs) are anticancer agents that affect gene expression and cellular responses.
  • HDIs can sometimes suppress the cellular antiviral response, potentially hindering OV efficacy.

Purpose of the Study:

  • To review the efficacy of combining OV therapy with HDI treatment.
  • To discuss the rationale and advantages of these combined therapeutic strategies.
  • To explore various OV/HDI combinations in cancer treatment.

Main Methods:

  • Review of pre-clinical and clinical studies on OV/HDI combinations.
  • Analysis of the synergistic effects of combining OVs and HDIs.
  • Evaluation of viral replication and cancer cell killing in vitro and in vivo.

Main Results:

  • Combination therapy of OVs and HDIs enhances viral replication.
  • Synergistic induction of cancer cell death observed in vitro and in vivo.
  • Demonstrated efficacy across various OV/HDI combinations.

Conclusions:

  • Combined OV and HDI therapy presents a synergistic approach to cancer treatment.
  • This combination enhances OV efficacy and overcomes limitations of standalone OV therapy.
  • Further research into OV/HDI combinations is warranted for improved cancer therapeutics.

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...