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Ketamine enantiomers and acetylcholinesterase
1National Defence Research Establishment, Division of Experimental Medicine, Umeå, Sweden.
Biochemical Pharmacology
|June 15, 1991
Abstract:
(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.