Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel dialysing seton: short-term biocompatibility.

P Richardson1, L N Walker, R L Cooper

  • 1Royal Perth Hospital, Western Australia.

Australian and New Zealand Journal of Ophthalmology
|February 1, 1991
PubMed
Summary

A novel biocompatible dialysing seton was tested in rabbit eyes, showing minimal inflammation and reduced intraocular pressure. This new device offers potential for glaucoma management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Event-by-Event Identification of Cherenkov Radiation from Sub-Mev Particles in Liquid Argon.

Physical review letters·2025
Same author

Retraction Note: SAR650984 directly induces multiple myeloma cell death via lysosomal-associated and apoptotic pathways, which is further enhanced by pomalidomide.

Leukemia·2024
Same author

First Leptophobic Dark Matter Search from the Coherent-CAPTAIN-Mills Liquid Argon Detector.

Physical review letters·2022
Same author

First Measurement of Coherent Elastic Neutrino-Nucleus Scattering on Argon.

Physical review letters·2021
Same author

Safety and tolerability of injectable Rilpivirine LA in HPTN 076: A phase 2 HIV pre-exposure prophylaxis study in women.

EClinicalMedicine·2020
Same author

First Measurement of the Total Neutron Cross Section on Argon between 100 and 800 MeV.

Physical review letters·2019

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Innovation

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Current treatments for glaucoma aim to reduce intraocular pressure (IOP).
  • Novel biomaterials are being explored for ocular implants.

Purpose of the Study:

  • To evaluate the biocompatibility of a novel dialysing seton in rabbit eyes.
  • To assess the effect of the seton on intraocular pressure (IOP).

Main Methods:

  • A novel dialysing seton made from haemodialysis tubes was implanted into eleven rabbit eyes.
  • Animals were observed for up to 67 days.
  • Histopathological analysis (light and electron microscopy) was performed on ocular tissues.
  • Intraocular pressure was measured and compared to sham-operated fellow eyes.

Related Experiment Videos

Main Results:

  • The dialysing seton demonstrated good clinical tolerance.
  • Histopathology revealed only mild inflammatory reactions, comparable to or less than nylon sutures.
  • Eyes with the seton showed consistently lower intraocular pressure for up to 24 days post-implantation.
  • The IOP-lowering effect diminished over the following five weeks.

Conclusions:

  • The novel dialysing seton is biocompatible for ocular implantation.
  • The seton effectively reduces intraocular pressure in the short term.
  • This device shows promise as a potential therapeutic option for glaucoma.