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Primary diffuse leptomeningeal gliomatosis: report of a case presenting with chronic meningitis

Sung-Hun Kim1, Dong-Chul Jun, Jin Se Park

  • 1Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|April 17, 2010
PubMed

Insights

Primary diffuse leptomeningeal gliomatosis is a rare brain tumor. This case highlights its presentation mimicking infectious meningitis, confirmed by leptomeningeal biopsy.

Area of Science:

  • Neuro-oncology
  • Neuropathology

Background:

  • Neoplastic meningitis affects ~5% of cancer patients.
  • Primary diffuse leptomeningeal gliomatosis is a rare glioma arising from heterotopic leptomeningeal cells.

Purpose of the Study:

  • To report a rare case of primary diffuse leptomeningeal gliomatosis.
  • To highlight diagnostic challenges and confirm the diagnosis via biopsy.

Main Methods:

  • Clinical case presentation.
  • Cerebrospinal fluid analysis (cytology).
  • Leptomeningeal biopsy and histopathological examination.

Main Results:

  • The patient presented with symptoms mimicking chronic infectious meningitis.
  • Cerebrospinal fluid cytology was negative for malignant cells.
  • Leptomeningeal biopsy confirmed primary diffuse leptomeningeal gliomatosis.

Conclusions:

  • Primary diffuse leptomeningeal gliomatosis can present insidiously with symptoms mimicking infectious meningitis.
  • Diagnosis requires a high index of suspicion and confirmation through leptomeningeal biopsy.
  • This rare condition poses significant diagnostic and therapeutic challenges.
Keywords:
Chronic meningitisPrimary diffuse leptomeningeal gliomatosis

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