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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Recurrent Cerebral Venous Thrombosis Associated with Elevated Factor VIII.
Mi Jung Kim1, A-Hyun Cho, Young-Joo No
1Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|April 17, 2010
Summary
Recurrent cerebral venous thrombosis (CVT) is rare. This case study highlights elevated factor VIII levels as a potential cause for CVT recurrence, even with antiplatelet use, suggesting longer anticoagulation may be needed.
Area of Science:
- Neurology
- Hematology
- Thrombosis Research
Background:
- Cerebral venous thrombosis (CVT) recurrence is infrequent, with causative factors often unidentified.
- Elevated plasma coagulation factor VIII is increasingly recognized as a risk factor for venous thromboembolism recurrence.
Purpose of the Study:
- To investigate potential factors contributing to recurrent cerebral venous thrombosis in a specific patient case.
- To explore the role of elevated coagulation factor levels in CVT recurrence.
Main Methods:
- Case report detailing a patient with recurrent CVT.
- Analysis of plasma coagulation factor levels, specifically factor VIII and factor IX.
- Assessment of the patient's current antiplatelet therapy.
Main Results:
- The patient experienced recurrent CVT despite chronic antiplatelet therapy.
- Significantly elevated levels of factor VIII were detected.
- Elevated factor IX levels were also observed in this patient.
Conclusions:
- Elevated factor VIII may be a significant underlying factor for cerebral venous thrombosis recurrence.
- Consideration of prolonged anticoagulation therapy is warranted for patients with elevated coagulation factor levels and recurrent CVT.
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