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Updated: Jun 13, 2026

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
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Smart microgel capsules from macromolecular precursors.

Sebastian Seiffert1, Julian Thiele, Adam R Abate

  • 1Harvard University, School of Engineering and Applied Sciences, 29 Oxford Street, Cambridge, Massachusetts 01238, USA. seiffert@seas.harvard.edu

Journal of the American Chemical Society
|April 20, 2010
PubMed
Summary

Researchers created novel, functional microgel capsules with two distinct, miscible layers using microfluidics. This breakthrough enables controlled morphology and prevents layer interpenetration, paving the way for advanced encapsulation technologies.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Microfluidics

Background:

  • Droplet microfluidics enable fabrication of multi-layered microgel particles and capsules.
  • Existing methods often rely on emulsion templating, limiting layer polarity to dissimilar types.
  • There is a need for methods to create microgel capsules with distinct, miscible layers.

Purpose of the Study:

  • To develop a microfluidic method for fabricating functional microgel capsules with two miscible yet distinct layers.
  • To control particle morphology and prevent significant interpenetration between layers.
  • To demonstrate the utility of these thermoresponsive core-shell microparticles for encapsulation and controlled release.

Main Methods:

  • Utilized microfluidic devices to template micrometer-sized drops.

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Last Updated: Jun 13, 2026

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  • Loaded drops with prepolymerized precursors (polyacrylamide and poly(N-isopropylacrylamide)).
  • Solidified precursors via a polymer-analogous reaction to form core-shell microparticles.

    • Main Results:

    • Successfully fabricated microgel capsules with two distinct, miscible layers.
    • Achieved controlled particle morphology and prevented pronounced interpenetration.
    • Demonstrated the thermoresponsive nature of poly(N-isopropylacrylamide) containing microparticles.
    • Showcased potential for encapsulation and controlled release applications.

    Conclusions:

    • A novel microfluidic approach allows for the creation of multi-layered microgel capsules with distinct, miscible layers.
    • The method provides control over particle morphology and layer integrity.
    • These functional microparticles are suitable for advanced encapsulation and controlled release systems.