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Internalizing versus externalizing comorbidity: neural circuit hypothesis.

Florence Levy1

  • 1School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia. f.levy@unsw.edu.au

The Australian and New Zealand Journal of Psychiatry
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

This study reviews the limbic system and cortico-striatal-thalamic-cortical (CSTC) circuits, proposing that childhood internalizing and externalizing syndromes stem from subcortical communication. Understanding these neural circuits offers new intervention targets.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Psychiatry

Background:

  • Historical debates surrounding the limbic system's role.
  • Emerging neurobiological insights into cortico-striatal-thalamic-cortical (CSTC) neural circuits.
  • The complex interplay between internalizing and externalizing childhood syndromes.

Purpose of the Study:

  • To update understanding of the limbic system using current neuroanatomy and neurobiology.
  • To propose a framework for understanding childhood internalizing-externalizing comorbidity via CSTC circuits.
  • To identify potential intervention targets within these neural circuits.

Main Methods:

  • Review of existing literature on the limbic system and CSTC circuits.
  • Neuroanatomical analysis of reciprocal and non-reciprocal connections within modular circuits.
  • Hypothesizing the role of subcortical communication in childhood behavioral comorbidities.

Main Results:

  • Advances in neuroanatomy and neurobiology offer new perspectives on the limbic system.
  • Excess communication within subcortical brain circuits is hypothesized to underlie childhood behavioral comorbidities.
  • A neuroanatomical model of CSTC circuits can explain internalizing-externalizing comorbidity.

Conclusions:

  • Understanding CSTC circuit connectivity is crucial for explaining childhood behavioral disorders.
  • Disruptions in goal orientation, Pavlovian, and operant processing within CSTC circuits are implicated.
  • Interventions targeting these specific functions within cortical-subcortical circuits may be effective.