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Related Concept Videos

Shearing Stress01:18

Shearing Stress

Shearing stress, denoted by the Greek letter tau (τ), is stress caused by forces acting transversely on an object. These forces create internal ones within the entity in the plane where the external forces are applied. The resultant of these internal forces is the shear in the section.
The average shearing stress can be calculated by dividing the shear by the area of the cross-section.
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Principal Stresses01:24

Principal Stresses

The graphical depiction of normal and shearing stress equations is represented by a circle, demonstrating the interplay between these stresses under different angular conditions. The center of this circle C, located on the vertical axis, represents the average normal stress, while its radius shows the range of stress variations. At points A and B, where the circle intersects the horizontal axis, the maximum and minimum normal stresses are observed, occurring without shearing stress. These...
Stress: General Loading Conditions01:15

Stress: General Loading Conditions

To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Components of Stress01:23

Components of Stress

Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
Interestingly, the hidden cube faces also experience these stresses, equal and opposite to those on the...

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Related Experiment Video

Updated: Jun 13, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Shear stress and plaque development.

Saurabh S Dhawan1, Ravi P Avati Nanjundappa, Jonathan R Branch

  • 1Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA.

Expert Review of Cardiovascular Therapy
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Atherosclerosis, a cardiovascular disease, develops site-specifically due to abnormal wall shear stress. This stress alters endothelial cells, promoting inflammation and plaque development, even with traditional risk factors present.

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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
07:51

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Published on: January 13, 2012

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

Area of Science:

  • Cardiovascular Biology
  • Biomedical Engineering
  • Pathophysiology

Background:

  • Traditional cardiovascular risk factors contribute to systemic atherogenesis.
  • Atherosclerosis exhibits site-specific predilection, favoring vessel curvatures and bifurcations.
  • Flow dividers are typically spared in atherosclerotic plaque development.

Purpose of the Study:

  • To explore the role of wall shear stress in the site-specific development of atherosclerosis.
  • To elucidate the pathobiology linking abnormal wall shear stress to atherosclerotic plaque formation and progression.

Main Methods:

  • Review of clinical and experimental data on atherosclerosis.
  • Analysis of endothelial cell responses to varying wall shear stress.
  • Investigation of molecular and cellular changes induced by wall shear stress.

Main Results:

  • Abnormal wall shear stress induces endothelial dysfunction, characterized by a proinflammatory phenotype.
  • Reduced nitric oxide availability and extracellular matrix disruption are consequences of abnormal wall shear stress.
  • These changes directly contribute to atherosclerotic plaque development and progression.

Conclusions:

  • Wall shear stress is a critical determinant of atherosclerotic lesion localization.
  • The pathobiology of atherosclerosis is significantly influenced by mechanical forces within blood vessels.
  • Targeting wall shear stress may offer novel therapeutic strategies for atherosclerosis.