Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thallium-201 distribution in the thyroid: relationship to thyroidal trapping function.

Z H Oster, H W Strauss, K Harrison

    Radiology
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Closing the Digitalis Divide: Back to the Basics of Randomized Controlled Trials.

    Cardiovascular drugs and therapy·2021
    Same author

    Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
    Same author

    Pulmonary tuberculosis diagnostic practices among people living with the human immunodeficiency virus in Lesotho.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
    Same author

    Impact of Hyperkalemia and Worsening Renal Function on the Use of Renin Angiotensin Aldosterone System Inhibitors in Chronic Heart Failure With Reduced Ejection Fraction.

    Clinical pharmacology and therapeutics·2017
    Same author

    Combined baseline and one-month changes in big endothelin-1 and brain natriuretic peptide plasma concentrations predict clinical outcomes in patients with left ventricular dysfunction after acute myocardial infarction: Insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study.

    International journal of cardiology·2017
    Same author

    Mineralocorticoid receptor blockade-a novel approach to fight hyperkalaemia in chronic kidney disease.

    Clinical kidney journal·2015

    Thallium-201 thyroid uptake in rats mirrors iodide uptake, suggesting it may reflect the iodide pump

    Area of Science:

    • Endocrinology
    • Nuclear Medicine
    • Physiology

    Background:

    • The thyroid gland actively transports iodide via the sodium-iodide symporter (NIS).
    • Understanding the behavior of radiotracers like thallium-201 in the thyroid is crucial for diagnostic imaging and research.

    Purpose of the Study:

    • To investigate the relationship between thallium-201 (Tl-201) uptake and the iodide-trapping mechanism in rat thyroids.
    • To determine if Tl-201 distribution can serve as an indicator of thyroidal iodide transport or blood flow.

    Main Methods:

    • Rats were intravenously injected with thallium-201.
    • Thyroidal uptake of Tl-201 was measured 30 minutes post-injection and compared to iodide uptake.
    • Uptake was assessed in control rats and in rats treated with thyroid-stimulating hormone (TSH), triiodothyronine (T3), or perchlorate.

    Related Experiment Videos

    Main Results:

    • Thallium-201 uptake in the thyroid paralleled iodide uptake in control rats.
    • TSH and T3 treatments affected Tl-201 uptake similarly to iodide uptake.
    • Perchlorate treatment, which inhibits iodide trapping, did not decrease Tl-201 concentration in the same manner as iodide concentration.

    Conclusions:

    • Thallium-201 uptake in the rat thyroid is closely linked to the iodide-trapping mechanism.
    • Thyroidal Tl-201 distribution may reflect the cationic transport function of the iodide pump.
    • Tl-201 distribution could also be influenced by thyroidal blood flow, warranting further investigation.